MUSCULAR SYSTEM

The muscular system is generally regarded as consisting of one type of muscle found in the body-skeletal muscle. However, there are two other types of muscle tissue found in the body, smooth muscle and cardiac muscle, that are important components of other systems. These three types of muscle can be characterized by whether they are controlled voluntarily or involuntarily, whether they appear striated (striped) or smooth, and whether they are associated with the body wall (somatic), or with organs and blood vessels (visceral). Skeletal muscle forms the majority of the muscle tissue in the body. It consists of parallel bundles of long, multinucleated fibers with transverse stripes, is capable of powerful contractions, and is innervated by somatic and branchial motor nerves. This muscle is used to move bones and other structures, and provides support and gives form to the body. Individual skeletal muscles are often named on the basis of shape (e.g., rhomboid major muscle), attachments (e.g., sternohyoid muscle), function (e.g., flexor pollicis longus muscle), position (e.g., palmar interosseous muscle), or fiber orientation (e.g., external oblique muscle). Cardiac muscle is striated muscle found only in the walls of the heart (myocardium) and in some of the large vessels close to where they join the heart. It consists of a branching network of individual cells linked electrically and mechanically to work as a unit. Its contractions are less powerful than those of skeletal muscle and it is resistant to fatigue. Cardiac muscle is innervated by visceral motor nerves. Smooth muscle (absence of stripes) consists of elongated or spindle-shaped fibers capable of slow and sustained contractions. It is found in the walls of blood vessels (tunica media), associated with hair follicles in the skin, located in the eyeball, and found in the walls of various structures associated with the gastrointestinal, respiratory, genitourinary, and urogenital systems. Smooth muscle is innervated by visceral motor nerves.

In the clinic

Muscle paralysis

Muscle paralysis is the inability to move a specific muscle or muscle group and may be associated with other neurological abnormalities, including loss of sensation. Paralysis may be due to abnormalities in the brain, the spinal cord, and the nerves supplying the muscles. Paralysis may also be caused by drugs that affect the neurotransmitters at the nerve endings and their action upon the muscle themselves. Major causes include stroke, trauma, poliomyelitis, and iatrogenic factors.

In the long term, muscle paralysis will produce secondary muscle wasting and overall atrophy of the region due to disuse.

Certain drugs used in anesthesia affect the neurotransmitters at the neuromuscular junction, in effect paralyzing the muscle. This has two results. First, it enables the operator to enter the region of the body without agonistic and antagonistic patient muscle response, making the procedure easier to perform. Second, muscle paralysis prevents the patient from breathing, which requires the anesthetist to mechanically ventilate the patient. Importantly, there are specific drugs that reverse the muscle paralysis drugs, which can be used at the end of the procedure.

In the clinic

Muscle injuries and strains

Muscle injuries and strains tend to occur in specific muscle groups and usually are related to a sudden exertion and muscle disruption. They typically occur in athletes.

Muscle tears may involve a small interstitial injury up to a complete muscle disruption (Fig. 1.27). It is important to identify which muscle groups are affected and the extent of the tear to facilitate treatment and obtain a prognosis, which will determine the length of rehabilitation necessary to return to normal activity.

 Figure 1.27 Axial inversion recovery series, which suppresses fat and soft tissue and leaves high signal intensity where fluid is seen. A muscle tear in the right adductor longus with edema in and around the muscle is shown.

In the clinic

Muscle atrophy

Muscle atrophy is a wasting disorder of muscle. It can be produced by a variety of causes, which include nerve damage to the muscle, and disuse.

Muscle atrophy is an important problem in patients who have undergone long-term rest or disuse, requiring extensive rehabilitation and muscle building exercises to maintain normal activities of daily living.

Muscle atrophy can be a considerable problem in the postsurgical patient who has undergone anterior cruciate ligament reconstruction. In patients with anterior cruciate ligament disruption there is often marked muscle wasting of the quadriceps, which occurs rapidly because of disuse. Before reconstruction of the cruciate ligament, patients will have to undergo a course of physiotherapy to increase muscle bulk. After the operation, this improved muscle bulk will lead to quicker return to normal daily living and will prevent the possibility of graft dysfunction.

Skin And Fascia

Skin

The skin is the largest organ of the body. It consists of the epidermis and the dermis. The epidermis is the outer cellular layer of stratified squamous epithelium, which is avascular and varies in thickness. The dermis is a dense bed of vascular connective tissue.

The skin functions as a mechanical and permeability barrier, and as a sensory and thermoregulatory organ. It also can initiate primary immune responses.

Fascia

Fascia is connective tissue containing varying amounts of fat that separate, support, and interconnect organs and structures, enable movement of one structure relative to another, and allow the transit of vessels and nerves from one area to another. There are two general categories of fascia: superficial and deep. Superficial (subcutaneous) fascia lies just deep to and is attached to the dermis of the skin. It is made up of loose connective tissue usually containing a large amount of fat. The thickness of the superficial fascia (subcutaneous tissue) varies considerably, both from one area of the body to another and from one individual to another. The superficial fascia allows movement of the skin over deeper areas of the body, acts as a conduit for vessels and nerves coursing to and from the skin, and serves as an energy (fat) reservoir. Deep fascia usually consists of dense, organized connective tissue. The outer layer of deep fascia is attached to the deep surface of the superficial fascia and forms a thin fibrous covering over most of the deeper region of the body. Inward extensions of this fascial layer form intermuscular septa that compartmentalize groups of muscles with similar functions and innervations. Other extensions surround individual muscles and groups of vessels and nerves, forming an investing fascia. Near some joints the deep fascia thickens, forming retinacula. These fascial retinacula hold tendons in place and prevent them from bowing during movements at the joints. Finally, there is a layer of deep fascia separating the membrane lining the abdominal cavity (the parietal peritoneum) from the fascia covering the deep surface of the muscles of the abdominal wall (the transversalis fascia). This layer is referred to as extraperitoneal fascia. A similar layer of fascia in the thorax is termed the endothoracic fascia.

In the clinic

The importance of fascias

A fascia is a thin band of tissue that surrounds muscles, bones, organs, nerves, and blood vessels and often remains uninterrupted as a three-dimensional structure between tissues. It provides important support for tissues and can provide a boundary between structures.

Fascias have specific dynamic properties and may be relatively elastic where necessary. They contain small blood vessels and tissue receptors and can respond to injury like any other tissue.

Clinically, fascias are extremely important because they often limit the spread of infection and malignant disease. When infection or malignant diseases cross a fascial plain, a primary surgical clearance may require a far more extensive dissection to render the area free of tumor or infection.

A typical example of a fascial layer would be that overlying the psoas muscle. Infection within an intervertebral body secondary to tuberculosis can pass laterally into the psoas muscle. Pus fills the psoas muscle but is limited from further spread by the psoas fascia, which surrounds the muscle and extends inferiorly into the groin pointing below the inguinal ligament.

Joints

The sites where two skeletal elements come together are termed joints. The two general categories of joints (Fig. 1.19) are those in which: the skeletal elements are separated by a cavity (i.e., synovial joints); and there is no cavity and the components are held together by connective tissue (i.e., solid joints).

Blood vessels that cross a joint and nerves that innervate muscles acting on a joint usually contribute articular branches to that joint.

Synovial joints

Synovial joints are connections between skeletal components where the elements involved are separated by a narrow articular cavity (Fig. 1.20). In addition to containing an articular cavity, these joints have a number of characteristic features.

First, a layer of cartilage, usually hyaline cartilage, covers the articulating surfaces of the skeletal elements. In other words, bony surfaces do not normally contact one another directly. As a consequence, when these joints are viewed in normal radiographs, a wide gap seems to separate the adjacent bones because the cartilage that covers the articulating surfaces is more transparent to X-rays than bone.

 Figure 1.19 Joints. A. Synovial joint. B. Solid joint.

A second characteristic feature of synovial joints is the presence of a joint capsule consisting of an inner synovial membrane and an outer fibrous membrane.

• The synovial membrane attaches to the margins of the joint surfaces at the interface between the cartilage and bone and encloses the articular cavity. The synovial membrane is highly vascular and produces synovial fluid, which percolates into the articular cavity and lubricates the articulating surfaces. Closed sacs of synovial membrane also occur outside joints where they form synovial bursae or tendon sheaths. Bursae often intervene between structures, such as tendons and bone, tendons and joints, or skin and bone, and reduce the friction of one structure moving over the other. Tendon sheaths surround tendons and also reduce friction.
• The fibrous membrane is formed by dense connective tissue and surrounds and stabilizes the joint. Parts of the fibrous membrane may thicken to form ligaments, which further stabilize the joint. Ligaments outside the capsule usually provide additional reinforcement.

 Figure 1.20 Synovial joints. A. Major features of a synovial joint. B. Accessory structures associated with synovial joints.

 Another common but not universal feature of synovial joints is the presence of additional structures within the area enclosed by the capsule or synovial membrane, such as articular discs (usually composed of fibrocartilage), fat pads, and tendons. Articular discs absorb compression forces, adjust to changes in the contours of joint surfaces during movements, and increase the range of movements that can occur at joints. Fat pads usually occur between the synovial membrane and the capsule and move into and out of regions as joint contours change during movement. Redundant regions of the synovial membrane and fibrous membrane allow for large movements at joints.

Descriptions of synovial joints based on shape and movement

Synovial joints are described based on shape and movement: based on the shape of their articular surfaces, synovial joints are described as plane (flat), hinge, pivot, bicondylar (two sets of contact points), condylar (ellipsoid), saddle, and ball and socket; based on movement, synovial joints are described as uniaxial (movement in one plane), biaxial (movement in two planes), and multi-axial (movement in three planes).

Hinge joints are uniaxial, whereas ball and socket joints are multi-axial.

Specific types of synovial joints (Fig. 1.21)

Plane joints-allow sliding or gliding movements when one bone moves across the surface of another (e.g., acromioclavicular joint) Hinge joints-allow movement around one axis that passes transversely through the joint; permit flexion and extension (e.g., elbow [humeroulnar] joint) Pivot joints-allow movement around one axis that passes longitudinally along the shaft of the bone; permit rotation (e.g., atlanto-axial joint) Bicondylar joints-allow movement mostly in one axis with limited rotation around a second axis; formed by two convex condyles that articulate with concave or flat surfaces (e.g., knee joint) Condylar (ellipsoid) joints-allow movement around two axes that are at right angles to each other; permit flexion, extension, abduction, adduction, and circumduction (limited) (e.g., wrist joint) Saddle joints-allow movement around two axes that are at right angles to each other; the articular surfaces are saddle shaped; permit flexion, extension, abduction, adduction, and circumduction (e.g., carpometacarpal joint of the thumb) Ball and socket joints-allow movement around multiple axes; permit flexion, extension, abduction, adduction, circumduction, and rotation (e.g., hip joint)

Solid joints

 Figure 1.21 Various types of synovial joints. A. Condylar (wrist). B. Gliding (radioulnar). C. Hinge or ginglymus (elbow). D. Ball and socket (hip). E. Saddle (carpometacarpal of thumb). F. Pivot (atlanto-axial).

Solid joints are connections between skeletal elements where the adjacent surfaces are linked together either by fibrous connective tissue or by cartilage, usually fibrocartilage (Fig. 1.22). Movements at these joints are more restricted than at synovial joints.

 Fibrous joints include sutures, gomphoses, and syndesmoses.

• Sutures occur only in the skull where adjacent bones are linked by a thin layer of connective tissue termed a sutural ligament.
• Gomphoses occur only between the teeth and adjacent bone. In these joints, short collagen tissue fibers in the periodontal ligament run between the root of the tooth and the bony socket.
• Syndesmoses are joints in which two adjacent bones are linked by a ligament. Examples are the ligamentum flavum, which connects adjacent vertebral laminae, and an interosseous membrane, which links, for example, the radius and ulna in the forearm.

Cartilaginous joints include synchondroses and symphyses.

• Synchondroses occur where two ossification centers in a developing bone remain separated by a layer of cartilage, for example the growth plate that occurs between the head and shaft of developing long bones. These joints allow bone growth and eventually become completely ossified.
• Symphyses occur where two separate bones are interconnected by cartilage. Most of these types of joints occur in the midline and include the pubic symphysis between the two pelvic bones, and intervertebral discs between adjacent vertebrae.

 Figure 1.22 Solid joints.

In the clinic

Degenerative joint disease

Degenerative joint disease is commonly known as osteoarthritis or osteoarthrosis. The disorder is related to aging but not caused by aging. Typically there are decreases in water and proteoglycan content within the cartilage. The cartilage becomes more fragile and more susceptible to mechanical disruption. As the cartilage wears, the underlying bone becomes fissured and also thickens. Synovial fluid may be forced into small cracks that appear in the bone's surface, which produces large cysts. Furthermore, reactive juxta-articular bony nodules are formed (osteophytes). As these processes occur, there is slight deformation, which alters the biomechanical forces through the joint. This in turn creates abnormal stresses, which further disrupt the joint (Figs. 1.23 and 1.24).

In the United States, osteoarthritis accounts for up to one-quarter of primary health care visits and is regarded as a significant problem.

The etiology of osteoarthritis is not clear; however, osteoarthritis can occur secondary to other joint diseases, such as rheumatoid arthritis and infection. Overuse of joints and abnormal strains, such as those experienced by people who play sports, often cause one to be more susceptible to chronic joint osteoarthritis.

Various treatments are available, including weight reduction, proper exercise, anti-inflammatory drug treatment, and joint replacement (Fig. 1.25).

Arthroscopy

Arthroscopy is a technique of visualizing the inside of a joint using a small telescope placed through a tiny incision in the skin. Arthroscopy can be performed in most joints. However, it is most commonly performed in the knee, shoulder, ankle, and hip joints. The elbow joint and wrist joint can also be viewed through the arthroscope.

Arthroscopy allows the surgeon to view the inside of the joint and its contents. Notably, in the knee, the menisci and the ligaments are easily seen, and it is possible using separate puncture sites and specific instruments to remove the menisci and replace the cruciate ligaments. The advantages of arthroscopy are that it is performed through small incisions, it enables patients to quickly recover and return to normal activity, and it only requires either a light anesthetic or regional anesthesia during the procedure.

Figure 1.23 This radiograph demonstrates the loss of joint space in the medial compartment and presence of small spiky osteophytic regions at the medial lateral aspect of the joint.

 Figure 1.25 Post-knee replacement. This radiograph shows the position of the prosthesis.

Figure 1.25 Post-knee replacement. This radiograph shows the position of the prosthesis.

Joint replacement

Joint replacement is undertaken for a variety of reasons. These predominantly include degenerative joint disease and joint destruction. Joints that have severely degenerated or lack their normal function are painful, which can be life limiting, and in otherwise fit and healthy individuals can restrict activities of daily living. In some patients the pain may be so severe that it prevents them from leaving the house and undertaking even the smallest of activities without discomfort.

Large joints are commonly affected, including the hip, knee, and shoulder. However, with ongoing developments in joint replacement materials and surgical techniques, even small joints of the fingers can be replaced.

Typically, both sides of the joint are replaced; in the hip joint the acetabulum will be reamed, and a plastic or metal cup will be introduced. The femoral component will be fitted precisely to the femur and cemented in place (Fig. 1.26).

Most patients derive significant benefit from joint replacement and continue to lead an active life afterward.

 Figure 1.26 This is a radiograph, anterior-posterior view, of the pelvis after a right total hip replacement. There are additional significant degenerative changes in the left hip joint, which will also need to be replaced.

Determination of skeletal age

Throughout life the bones develop in a predictable way to form the skeletally mature adult at the end of puberty. In western countries skeletal maturity tends to occur between the ages of 20 and 25 years. However, this may well vary according to geography and socioeconomic conditions. Skeletal maturity will also be determined by genetic factors and disease states.

Up until the age of skeletal maturity, bony growth and development follows a typically predictable ordered state, which can be measured through either ultrasound, plain radiographs, or MRI scanning. Typically, the nondominant (left hand) is radiographed and is compared to a series of standard radiographs. From these images the bone age can be determined (Fig. 1.13).

In certain disease states, such as malnutrition and hypothyroidism, bony maturity may be slow. If the skeletal bone age is significantly reduced from the patient's true age, treatment may be required.

In the healthy individual the bone age accurately represents the true age of the patient. This is important in determining the true age of the subject. This may also have medicolegal importance.

In the clinic

Determination of skeletal age

Throughout life the bones develop in a predictable way to form the skeletally mature adult at the end of puberty. In western countries skeletal maturity tends to occur between the ages of 20 and 25 years. However, this may well vary according to geography and socioeconomic conditions. Skeletal maturity will also be determined by genetic factors and disease states.

Up until the age of skeletal maturity, bony growth and development follows a typically predictable ordered state, which can be measured through either ultrasound, plain radiographs, or MRI scanning. Typically, the nondominant (left hand) is radiographed and is compared to a series of standard radiographs. From these images the bone age can be determined (Fig. 1.13).

In certain disease states, such as malnutrition and hypothyroidism, bony maturity may be slow. If the skeletal bone age is significantly reduced from the patient's true age, treatment may be required.

In the healthy individual the bone age accurately represents the true age of the patient. This is important in determining the true age of the subject. This may also have medicolegal importance.

Figure 1.13 A developmental series of radiographs showing the progressive ossification of carpal (wrist) bones from 3(A) to 10(E) years of age.

Bone marrow transplants

The bone marrow serves an important function. There are two types of bone marrow, the red marrow (otherwise known as myeloid tissue) and the yellow marrow. Red blood cells, platelets, and most white blood cells arise from within the red marrow. In the yellow marrow a few white cells are made; however this marrow is dominated by large fat globules (producing its yellow appearance) (Fig. 1.14).

From birth most of the body's marrow is red; however, as the subject ages, more red marrow is converted into yellow marrow within the medulla of the long and flat bones.

Bone marrow contains two types of stem cells. Hemopoietic stem cell grafts give rise to the white blood cells, red blood cells, and platelets. Mesenchymal stem cells differentiate into structures that form bone, cartilage, and muscle.

There are a number of diseases that may involve the bone marrow, including infection and malignancy. In patients who develop a bone marrow malignancy (e.g., leukemia) it may be possible to harvest nonmalignant cells from the patient's bone marrow or cells from another person's bone marrow. The patient's own marrow can be destroyed with chemotherapy or radiation and the new cells infused. This treatment is bone marrow transplantation.

 Figure 1.14 T1-weighted image in the coronal plane, demonstrating the relatively high signal intensity returned from the femoral heads and proximal femoral necks, consistent with yellow marrow. In this young patient, the vertebral bodies return an intermediate darker signal that represents red marrow. There is relatively little fat in these vertebrae, hence the lower signal return.

In the clinic

Bone fractures

Fractures occur in normal bone because of abnormal load or stress, in which the bone gives way. Fractures may also occur in bone that is of poor quality (osteoporosis); in such cases a normal stress is placed upon a bone that is not of sufficient quality to withstand this force and subsequently fractures.

In children whose bones are still developing, fractures may occur across the growth plate or across the shaft. These shaft fractures typically involve partial cortical disruption, similar to breaking a branch of a young tree; hence they are termed "greenstick" fractures (Fig. 1.15).

After a fracture has occurred, the natural response is to heal the fracture. Between the fracture margins a blood clot is formed into which new vessels grow. A jelly-like matrix is formed, and further migration of collagen-producing cells occurs. On this soft tissue framework, calcium hydroxyapatite is produced by osteoblasts and forms insoluble crystals, and then bone matrix is laid down. As more bone is produced, a callus can be demonstrated forming across the fracture site.Treatment of fractures requires a fracture line reduction. If this cannot be maintained in plaster of Paris cast, it may require internal or external fixation with screws and metal rods.

 Figure 1.15 Radiograph, lateral view, showing greenstick fractures of the distal radius and distal ulna.

Avascular necrosis

Avascular necrosis is cellular death of bone resulting from a temporary or permanent loss of blood supply to that bone. Avascular necrosis may occur in a variety of medical conditions, some of which have an etiology that is less than clear. A typical site for avascular necrosis is a fracture across the femoral neck in an elderly patient. In these patients there is loss of continuity of the cortical medullary blood flow with loss of blood flow deep to the retinacular fibers. This essentially renders the femoral head bloodless; it subsequently undergoes sclerosis and collapse. In these patients it is necessary to replace the femoral head with a prosthesis (Fig. 1.16).

 Figure 1.16 Image of the hip joints demonstrating loss of height of the right femoral head with juxta-articular bony sclerosis and subchondral cyst formation secondary to avascular necrosis. There is also significant wasting of the muscles supporting the hip, which is secondary to disuse and pain.

In the clinic
Osteoporosis

 Figure 1.17 Radiograph of the lumbar region of the vertebral column demonstrating a wedge fracture of the L1 vertebra. This condition is typically seen in patients with osteoporosis.

Osteoporosis is a disease in which the bone mineral density is significantly reduced. This renders the bone significantly more at risk of fracture. Typically, osteoporotic fractures occur in the femoral necks, the vertebra, and the wrist. Although osteoporosis may occur in men, especially elderly men, the typical patients are postmenopausal women. There are a number of risk factors that predispose bones to develop osteoporosis. These factors include poor diet, steroid usage, smoking, and premature ovarian failure. Treatment involves removing underlying potentiating factors, such as improving diet and preventing further bone loss with drug treatment, (e.g., vitamin D and calcium supplements; newer treatments include drugs that increase bone mineral density) (Figs. 1.17 and 1.18).

Figure 1.18 Radiograph of the lumbar region of the vertebral column demonstrating three intra-pedicular needles, all of which have been placed into the middle of the vertebral bodies. The high-density material is radiopaque bone cement, which has been injected as a liquid to set solid. 

Epiphyseal fractures

As the skeleton develops, there are stages of intense growth typically around the ages of 7 to 10 years and later in puberty. These growth spurts are associated with increased cellular activity around the growth plate and the metaphyseal region. This increase in activity renders the growth plates and metaphyseal regions more vulnerable to injuries, which may occur from dislocation across a growth plate or fracture through a growth plate. Occasionally an injury may result in growth plate compression, destroying that region of the growth plate, which may result in asymmetric growth across that joint region. All fractures across the growth plate must be treated with care and expediency, requiring fracture reduction.

SKELETAL SYSTEM

The skeleton can be divided into two subgroups, the axial skeleton and the appendicular skeleton. The axial skeleton consists of the bones of the skull (cranium), vertebral column, ribs, and sternum, whereas the appendicular skeleton consists of the bones of the upper and lower limbs (Fig. 1.12).

The skeletal system consists of cartilage and bone.

Cartilage

Cartilage is an avascular form of connective tissue consisting of extracellular fibers embedded in a matrix that contains cells localized in small cavities. The amount and kind of extracellular fibers in the matrix varies depending on the type of cartilage. In heavy weightbearing areas or areas prone to pulling forces, the amount of collagen is greatly increased and the cartilage is almost inextensible. In contrast, in areas where weightbearing demands and stress are less, cartilage containing elastic fibers and fewer collagen fibers is common. The functions of cartilage are to: support soft tissues; provide a smooth, gliding surface for bone articulations at joints; and enable the development and growth of long bones.

There are three types of cartilage:

• hyaline-most common; matrix contains a moderate amount of collagen fibers (e.g., articular surfaces of bones);
• elastic:-matrix contains collagen fibers along with a large number of elastic fibers (e.g., external ear);
• fibrocartilage-matrix contains a limited number of cells and ground substance amidst a substantial amount of collagen fibers (e.g., intervertebral discs). Cartilage is nourished by diffusion and has no blood vessels, lymphatics, or nerves. 

Bone

Bone is a calcified, living, connective tissue that forms the majority of the skeleton. It consists of an intercellular calcified matrix, which also contains collagen fibers, and several types of cells within the matrix. Bones function as: supportive structures for the body; protectors of vital organs; reservoirs of calcium and phosphorus; levers on which muscles act to produce movement; and containers for blood-producing cells.

There are two types of bone, compact and spongy (trabecular or cancellous). Compact bone is dense bone that forms the outer shell of all bones and surrounds spongy bone. Spongy bone consists of spicules of bone enclosing cavities containing blood-forming cells (marrow). Classification of bones is by shape. Long bones are tubular (e.g., humerus in upper limb; femur in lower limb). Short bones are cuboidal (e.g., bones of the wrist and ankle). Flat bones consist of two compact bone plates separated by spongy bone (e.g., skull). Irregular bones are bones with various shapes (e.g., bones of the face). Sesamoid bones are round or oval bones that develop in tendons.

Bones are vascular and are innervated. Generally, an adjacent artery gives off a nutrient artery, usually one per bone, that directly enters the internal cavity of the bone and supplies the marrow, spongy bone, and inner layers of compact bone. In addition, all bones are covered externally, except in the area of a joint where articular cartilage is present, by a fibrous connective tissue membrane called the periosteum, which has the unique capability of forming new bone. This membrane receives blood vessels whose branches supply the outer layers of compact bone. A bone stripped of its periosteum will not survive. Nerves accompany the vessels that supply the bone and the periosteum. Most of the nerves passing into the internal cavity with the nutrient artery are vasomotor fibers that regulate blood flow. Bone itself has few sensory nerve fibers. On the other hand, the periosteum is supplied with numerous sensory nerve fibers and is very sensitive to any type of injury.

Developmentally, all bones come from mesenchyme by either intramembranous ossification, in which mesenchymal models of bones undergo ossification, or endochondral ossification, in which cartilaginous models of bones form from mesenchyme and undergo ossification.